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Bowen's Disease Associated With Two Human Papilloma Virus Types
Hojat Eftekhari1, Kaveh Gharaei Nejad1, Seyyede Zeinab Azimi1
1Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Acta Medica Iranica
|December 6, 2017
Summary
Bowen's disease, a type of skin cancer, can present atypically. This case highlights Human Papilloma Virus (HPV) types 6 and 18 co-infection in an unusual presentation of Bowen's disease.
Area of Science:
- Dermatology
- Oncology
- Virology
Background:
- Bowen's disease (BD) is a form of squamous cell carcinoma in situ (SCCIS).
- Human Papilloma Virus (HPV) positivity is common in BD, particularly HPV type-16.
- HPV-positive BD typically affects the genital region or periungual sites.
Observation:
- A 64-year-old male construction worker presented with erythematous, psoriasiform, reticular, scaly plaques.
- Lesions were located on the peri-umbilical area and medial knee, an atypical location for BD.
- Biopsy confirmed Bowen's disease.
Findings:
- Polymerase chain reaction (PCR) assay detected co-infection with HPV types 6 and 18.
- This HPV co-infection was identified in an unusual presentation of Bowen's disease.
Implications:
- This case expands the understanding of atypical presentations of Bowen's disease.
- It underscores the importance of considering HPV co-infections beyond HPV-16 in diverse anatomical locations.
- Highlights the need for comprehensive diagnostic approaches in dermatology.
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