Related Experiment Video
Updated: Feb 17, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
Persistent Opioid Use Among Pediatric Patients After Surgery
Calista M Harbaugh1, Jay S Lee1, Hsou Mei Hu2
1Sections of General Surgery.
Opioid use after surgery is common in young patients, with 4.8% experiencing persistent use. This highlights a potential pathway to prescription opioid misuse in adolescents and young adults.
Area of Science:
- Pain Management
- Adolescent Health
- Pharmacology
Background:
- Nonmedical opioid misuse remains a public health concern.
- Limited understanding of persistent opioid use post-surgery in young populations.
Purpose of the Study:
- To investigate the incidence of prolonged opioid refills in adolescents and young adults after surgery.
- To compare persistent opioid use in surgical versus non-surgical patients.
Main Methods:
- Retrospective cohort study using commercial claims data (2010-2014).
- Included opioid-naïve patients aged 13-21 undergoing specific surgeries.
- Defined persistent opioid use as ≥1 refill between 90-180 days post-procedure.
Main Results:
- 60.5% of eligible patients received postoperative opioids.
- Persistent opioid use occurred in 4.8% of surgical patients vs. 0.1% of non-surgical controls.
- Cholecystectomy and colectomy showed higher risks; older age, female sex, substance use disorder, and preoperative opioid use were risk factors.
Conclusions:
- Postoperative persistent opioid use is a significant concern in adolescents and young adults.
- This may be a critical pathway to prescription opioid misuse.
- Prioritizing safe, evidence-based pain management is crucial, especially for at-risk individuals.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Opioid Analgesics: Morphine and Other Natural Cogeners
Analgesia and Pain Management
Prescription, Nonprescription and Orphan Drugs
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Parenteral Anesthetics: Overview
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...

