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Updated: Feb 17, 2026
Author Spotlight: Automated Bioprinting for High-Throughput Vascular Model Fabrication
Published on: August 16, 2024
A highly printable and biocompatible hydrogel composite for direct printing of soft and perfusable vasculature-like
Ratima Suntornnond1, Edgar Yong Sheng Tan2, Jia An2
1Singapore Centre for 3D Printing, School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore. ratima001@e.ntu.edu.sg.
Abstract:
Vascularization is one major obstacle in bioprinting and tissue engineering. In order to create thick tissues or organs that can function like original body parts, the presence of a perfusable vascular system is essential. However, it is challenging to bioprint a hydrogel-based three-dimensional vasculature-like structure in a single step. In this paper, we report a new hydrogel-based composite that offers impressive printability, shape integrity, and biocompatibility for 3D bioprinting of a perfusable complex vasculature-like structure. The hydrogel composite can be used on a non-liquid platform and is printable at human body temperature. Moreover, the hydrogel composite supports both cell proliferation and cell differentiation. Our results represent a potentially new vascularization strategy for 3D bioprinting and tissue engineering.
