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A Meta-Analysis of Adalimumab for Fistula in Crohn's Disease

Yin-Mei Fu1, Ming Chen1, Ai-Jun Liao1

  • 1Department of Gastroenterology and Hepatology, First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China.

Gastroenterology Research and Practice
|December 6, 2017
PubMed

Insights

Adalimumab (ADA) is an effective and safe treatment for fistula in Crohn

Area of Science:

  • Gastroenterology and immunology
  • Therapeutic drug evaluation

Background:

  • Crohn's disease (CD) is a chronic inflammatory condition.
  • Fistula formation is a common and debilitating complication of CD.

Purpose of the Study:

  • To evaluate the therapeutic value and efficacy of adalimumab (ADA) in treating fistula in patients with Crohn's disease.

Main Methods:

  • A comprehensive meta-analysis was conducted.
  • Searched electronic databases (PubMed, Web of Science, Embase, Google Scholar, Cochrane Library) from 2000 to October 2016.
  • Included randomized controlled trials (RCTs) and non-randomized controlled trials (N-RCTs), assessing study quality with MINORS criteria.

Main Results:

  • Seven studies involving 379 patients met the inclusion criteria.
  • Adalimumab treatment resulted in complete fistula closure in 36% of CD patients.
  • Partial response was observed in 31% of patients receiving ADA therapy.

Conclusions:

  • Adalimumab (ADA) demonstrates significant efficacy and a favorable safety profile for managing fistula in Crohn's disease.
  • Current evidence supports ADA as a valuable therapeutic option for this CD complication.
Abstract

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