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Related Experiment Video

Updated: Feb 17, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

Leukemia Stem Cells Microenvironment.

Yoko Tabe^1,2, Marina Konopleva³

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Advances in Experimental Medicine and Biology

|December 6, 2017

Summary

Leukemia stem cells (LSCs) hijack bone marrow niches, creating sanctuaries that promote drug resistance and leukemia growth. Understanding these microenvironment interactions is key to LSC survival and therapeutic strategies.

Keywords:

Microenvironment Niche Stem cell

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Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

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Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

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Modeling Chemotherapy Resistant Leukemia In Vitro

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

Area of Science:

Hematology
Cancer Biology
Stem Cell Biology

Background:

Leukemia stem cells (LSCs) reside within the bone marrow (BM) microenvironment.
The BM microenvironment comprises niches that regulate LSC properties and survival.
LSCs interact with BM cells, influencing their own behavior and the niche.

Purpose of the Study:

To describe the key components and regulation of BM niches in leukemic BM.
To discuss metabolic changes in LSCs and their role in survival.
To elucidate the mechanisms by which BM niches contribute to therapeutic resistance.

Main Methods:

Review of recent research on normal and leukemia BM microenvironments.
Analysis of molecular pathways involved in microenvironment/leukemia interactions.
Discussion of LSC metabolic alterations.

Main Results:

Specific niches within the BM microenvironment act as sanctuaries for leukemia cells.
These niches shield LSCs from chemotherapy, promoting drug resistance.
LSCs outcompete normal hematopoietic stem cells (HSCs) and hijack BM niches.

Conclusions:

The BM microenvironment plays a critical role in leukemia progression and therapeutic resistance.
Understanding niche-leukemia interactions and LSC metabolism is crucial for developing novel treatments.
Both microenvironment-induced oncogenesis and malignancy-induced microenvironment concepts are relevant.