Related Experiment Video
Updated: Feb 17, 2026
06:59
Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
Published on: August 26, 2025
620
Aspirin for Prophylaxis Against Venous Thromboembolism After Orthopaedic Oncologic Surgery
Gregory M Mendez1, Yash M Patel2, Daniel A Ricketti3
1Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, Cooper University Health Care, Camden, New Jersey.
The Journal of Bone and Joint Surgery. American Volume
|December 6, 2017
Summary
Aspirin effectively reduced venous thromboembolism (VTE) risk in patients undergoing orthopedic oncology surgery. This study suggests aspirin is a suitable VTE chemoprophylaxis option, particularly for soft-tissue sarcoma patients.
Area of Science:
- Orthopaedic Surgery
- Oncology
- Vascular Medicine
Background:
- Patients undergoing orthopedic oncologic surgery face a high risk of venous thromboembolism (VTE).
- Current guidelines are evolving to consider aspirin for postoperative VTE prophylaxis.
Purpose of the Study:
- To evaluate the effectiveness of aspirin in preventing VTE after orthopedic oncologic procedures.
- To analyze the institution's experience with aspirin as a VTE prophylactic agent.
Main Methods:
- Retrospective review of 130 patients (142 procedures) with primary bone/soft-tissue tumors or metastatic carcinoma.
- Analysis of demographic data, diagnoses, VTE history, surgical procedures, and prophylaxis methods (aspirin vs. non-aspirin).
- Comparison of VTE rates between aspirin and non-aspirin prophylaxis groups.
Main Results:
- Overall VTE rate was 4.9% (7/142 procedures).
- Aspirin prophylaxis (n=103) had a VTE rate of 2.9% compared to 10.3% for non-aspirin prophylaxis (n=39).
- No VTEs occurred in aspirin-treated patients with metastatic carcinoma, soft-tissue sarcoma, lymphoma, or multiple myeloma.
Conclusions:
- Aspirin appears to be a safe and effective option for VTE chemoprophylaxis in orthopedic oncology patients.
- Aspirin may be particularly beneficial for patients with soft-tissue sarcoma.
- Further research with advanced study designs is recommended.
Related Concept Videos
01:29Venous Thrombosis III: Interprofessional Care
388
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
388
01:30Venous Thrombosis IV: Nursing Management
278
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
278
01:23Peripheral Artery Disease V: Postoperative Nursing Management
430
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
430
01:22Aneurysm IV: Nursing Management
488
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
488
01:27Pulmonary Embolism III: Nursing Management
467
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
467
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
2.0K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.0K