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Using Looming Visual Stimuli to Evaluate Mouse Vision

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Published on: June 13, 2019

Cortical Processing: How Mice Predict the Visual Effects of Locomotion.

Marina Fridman¹, Leopoldo Petreanu¹

¹Champalimaud Research, Champalimaud Center for the Unknown, Lisbon, Portugal.

Current Biology : CB

|December 6, 2017

Summary

Researchers found a frontal brain region in mice that predicts visual motion during movement. This discovery supports predictive coding models of brain function.

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Last Updated: Feb 17, 2026

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Area of Science:

Neuroscience
Computational Neuroscience
Systems Neuroscience

Background:

The brain processes sensory information, integrating it with motor commands.
Predictive coding theories propose the brain anticipates sensory input based on internal models.

Purpose of the Study:

To identify brain regions involved in predicting visual flow during locomotion.
To investigate the neural mechanisms underlying predictive coding in the neocortex.

Main Methods:

Utilized in vivo calcium imaging in mice to monitor neural activity.
Recorded neuronal responses in the frontal cortex and visual cortex during locomotion tasks.

Main Results:

Identified a specific frontal cortical area projecting to the visual cortex.
Demonstrated that this frontal area generates predictive signals of locomotion-coupled visual flow.

Conclusions:

This frontal region plays a key role in predictive sensory processing.
The findings provide evidence for predictive coding mechanisms in cortical circuits.