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Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Related Experiment Video

Updated: Feb 17, 2026

Murine Bilateral Renal Lymphadenectomy
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Published on: December 30, 2025

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Autoimmune and medication-induced lymphadenopathies.

Alejandro A Gru1, Dennis P O'Malley2

  • 1Departments of Pathology & Dermatology, University of Virginia, Charlottesville, VA, USA.

Seminars in Diagnostic Pathology
|December 7, 2017
PubMed
Summary

This review discusses autoimmune disorders and medication side effects that can mimic lymphoma in lymph nodes. Key findings include architectural preservation in autoimmune conditions, aiding differential diagnosis from lymphomas.

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Area of Science:

  • Pathology
  • Immunology
  • Oncology

Background:

  • Autoimmune disorders can present with lymphadenopathy, mimicking lymphoproliferative diseases.
  • Pediatric conditions like autoimmune lymphoproliferative syndrome and Kawasaki disease, and adult conditions like rheumatoid arthritis, lupus, and sarcoidosis, affect lymph nodes.
  • Medication-induced lymph node alterations range from hyperplasia to lymphoproliferative disorders.

Purpose of the Study:

  • To review common autoimmune disorders affecting lymph nodes.
  • To discuss medication-induced lymph node pathologies.
  • To highlight features distinguishing these conditions from B and T-cell lymphomas.

Main Methods:

  • Review of literature on autoimmune disorders and lymph node pathology.
  • Analysis of histopathological features in affected lymph nodes.
  • Correlation of clinical presentation with pathological findings.

Main Results:

  • Autoimmune disorders often show relative preservation of lymph node architecture, differentiating them from lymphomas.
  • Specific autoimmune conditions like autoimmune lymphoproliferative syndrome, Kawasaki disease, rheumatoid arthritis, lupus, and sarcoidosis are discussed.
  • Medication side effects can cause reactive hyperplasia or lymphoproliferative disorders, notably with methotrexate and TNF-inhibitors.

Conclusions:

  • Understanding autoimmune lymphadenopathy and drug-induced changes is crucial for accurate diagnosis.
  • Relative architectural preservation is a key feature distinguishing these mimics from lymphomas.
  • Careful clinicopathological correlation is essential for differentiating benign or drug-related lymph node conditions from malignant lymphomas.