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Updated: Feb 17, 2026

DNA-affinity-purified Chip DAP-chip Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
Published on: July 21, 2014
Two-component signal transduction systems in oral bacteria
Renata O Mattos-Graner1, Margaret J Duncan2
1Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas - UNICAMP, São Paulo, Brazil.
Abstract:
We present an overview of how members of the oral microbiota respond to their environment by regulating gene expression through two-component signal transduction systems (TCSs) to support conditions compatible with homeostasis in oral biofilms or drive the equilibrium toward dysbiosis in response to environmental changes. Using studies on the sub-gingival Gram-negative anaerobe Porphyromonas gingivalis and Gram-positive streptococci as examples, we focus on the molecular mechanisms involved in activation of TCS and species specificities of TCS regulons.
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