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Related Experiment Video

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Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
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Hepatocarcinogenesis and LI-RADS.

Kazim H Narsinh1,2, Jennifer Cui1, Demetri Papadatos3

  • 1Liver Imaging Group, Department of Radiology, University of California San Diego, 200 W. Arbor Drive #8756, San Diego, CA, 92103, USA.

Abdominal Radiology (New York)
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PubMed
Summary

Understanding hepatocarcinogenesis, the development of liver cancer, aids early hepatocellular carcinoma (HCC) diagnosis. Recognizing imaging features linked to cellular changes improves detection and management of this common cancer.

Keywords:
CTHepatocarcinogenesisHepatocellular carcinomaLI-RADSLiverMRI

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Area of Science:

  • Hepatology and oncology
  • Radiology and medical imaging

Background:

  • Hepatocarcinogenesis involves progressive dedifferentiation of hepatocytes.
  • Early diagnosis of hepatocellular carcinoma (HCC) is crucial for patient outcomes.
  • Imaging features reflect molecular and cellular changes during cancer development.

Purpose of the Study:

  • To review the cellular and molecular alterations in hepatocarcinogenesis.
  • To correlate these changes with abnormal imaging features.
  • To highlight the relevance of these features for the Liver Imaging Reporting and Data System (LI-RADS).

Main Methods:

  • Review of scientific literature on hepatocarcinogenesis.
  • Analysis of imaging findings associated with liver cancer progression.
  • Examination of LI-RADS v2017 criteria.

Main Results:

  • Hepatocarcinogenesis leads to distinct cellular and molecular changes.
  • These alterations manifest as specific, recognizable abnormal imaging features.
  • Many key imaging features are incorporated into LI-RADS v2017.

Conclusions:

  • Familiarity with hepatocarcinogenesis mechanisms enhances the interpretation of liver imaging.
  • Understanding imaging features aids in the early and accurate diagnosis of HCC.
  • LI-RADS v2017 incorporates critical imaging biomarkers for HCC detection.