Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

23.7K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
23.7K
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.2K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.2K
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

5.2K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
5.2K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

9.7K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
9.7K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

16.0K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
16.0K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

7.1K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
7.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lower LDL-c/ApoB ratio is associated with adverse cardiovascular outcomes and advanced peripheral artery disease.

VASA. Zeitschrift fur Gefasskrankheiten·2026
Same author

Downhill-walking exercise training in a patient with symptomatic peripheral artery disease: A case report.

Vascular medicine (London, England)·2026
Same author

Peripheral artery disease: time to recognize the systemic burden and reorganize care.

European journal of preventive cardiology·2026
Same author

[The Role of Nailfold Capillaroscopy in Raynaud's Phenomenon and Autoimmune Diseases].

Revue medicale suisse·2026
Same author

Assessing preferred walking speed in patients with symptomatic chronic peripheral artery disease: Comparison of the 4-versus 10-meter walk test.

Vascular medicine (London, England)·2026
Same author

Structured exercise training and rehabilitation in patients with acute venous thromboembolism: a systematic review of randomized controlled trials.

European journal of preventive cardiology·2026

Related Experiment Video

Updated: Feb 17, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

15.0K

[Primary lymphedema].

Michèle Depairon1, Claudia Lessert1, Didier Tomson1

  • 1Service d'angiologie, Départment coeur-vaisseaux, CHUV, 1011 Lausanne.

Revue Medicale Suisse
|December 7, 2017
PubMed
Summary
This summary is machine-generated.

Primary lymphedema, a rare disease affecting the lymphatic network, often presents before age 35. Early identification and multidisciplinary care are crucial for managing this condition and supporting affected families.

More Related Videos

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
09:50

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

8.7K
A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

6.7K

Related Experiment Videos

Last Updated: Feb 17, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

15.0K
A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
09:50

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

8.7K
A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

6.7K

Area of Science:

  • Vascular Medicine
  • Genetics
  • Rare Diseases

Background:

  • Primary lymphedema results from lymphatic network abnormalities (aplasia, hypoplasia, dysplasia).
  • It is considered a rare disease, with 10% of cases being congenital.
  • The majority of cases are diagnosed before 35 years, often triggered by infections or sprains.

Purpose of the Study:

  • To summarize the characteristics and management of primary lymphedema.
  • To highlight the genetic and syndromic associations of primary lymphedema.
  • To emphasize the importance of early diagnosis and comprehensive care.

Main Methods:

  • Literature review of primary lymphedema.
  • Analysis of etiological factors and clinical presentation.
  • Discussion of current management strategies.

Main Results:

  • Primary lymphedema encompasses congenital and non-congenital forms, with familial subtypes like Milroy and Meige syndromes.
  • It can be associated with complex genetic syndromes (Klinefelter, Turner, Noonan).
  • Lymphatic drainage and elastic compression are foundational treatments.

Conclusions:

  • Early identification of patients and their families is essential.
  • Multidisciplinary care approaches are often necessary for effective management.
  • Understanding the diverse origins of primary lymphedema informs patient care.