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Growth and neurodevelopment in very preterm infants receiving a high enteral volume-feeding regimen - a

Claus Klingenberg1,2, Fredrik Kragh Muraas3, Catherine Elde Isaksen4

  • 1a Division of Child and Adolescent Health, Department of Paediatrics , University Hospital of North Norway , Tromsø , Norway.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|December 8, 2017
PubMed

Insights

High volumes of fortified human milk safely support growth and development in very preterm infants. This feeding regimen led to good head growth and improved language development, with low rates of growth restriction.

Area of Science:

  • Neonatal Nutrition and Growth
  • Developmental Pediatrics
  • Clinical Nutrition

Background:

  • Optimizing nutrition for very preterm infants is critical for growth and neurodevelopment.
  • Previous feeding regimens may not achieve adequate intake for optimal outcomes.
  • Human milk fortification is standard practice for preterm infants.

Purpose of the Study:

  • To evaluate a feeding regimen providing >180 ml/kg/d of fortified human milk to very preterm infants.
  • To assess the impact of this regimen on in-hospital growth, osteopenia, and neurodevelopment.

Main Methods:

  • Retrospective, population-based descriptive study of infants <30-week gestation.
  • Infants admitted between 2005-2010, with follow-up to 2 years corrected age.
  • Analysis of growth, head circumference, blood values for osteopenia, and neurodevelopmental outcomes.

Main Results:

  • High enteral feeding volumes (average 193 ml/kg/d) were achieved.
  • Low rates of in-hospital growth restriction (14% below 10th percentile at discharge) and stable head circumference Z-scores were observed.
  • No indicators of osteopenia were found; improved head growth correlated with better language development.

Conclusions:

  • A high enteral feeding volume regimen of fortified human milk is safe and feasible for very preterm infants.
  • This approach is associated with favorable in-hospital growth and neurodevelopmental outcomes.
  • High enteral volume intake may enhance nutritional status in this vulnerable population.
Abstract

Keywords:
Breast milkenteral nutritionfeeding volumeinfantnewbornpreterm

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