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The Potential of microRNAs for Stem Cell-based Therapy for Degenerative Skeletal Diseases

Emma Budd1, Shona Waddell1, María C de Andrés1

  • 1Bone & Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD UK.

Current Molecular Biology Reports
|December 8, 2017
PubMed
Abstract

Insights

Combining stem cells with microRNAs (miRNAs) shows promise for regenerating bone and cartilage. This approach offers potential new therapies for osteoarthritis and osteoporosis, addressing unmet clinical needs in skeletal regeneration.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Degenerative skeletal disorders like osteoarthritis (OA) and osteoporosis (OP) stem from impaired tissue regeneration, causing pain and limited treatment options.
  • Preventative strategies for OA and OP are crucial unmet clinical needs.
  • MicroRNAs (miRNAs) regulate stem cell differentiation, suggesting a role in skeletal repair.

Purpose of the Study:

  • To review the potential of combining skeletal stem cells (SSCs) with microRNAs (miRNAs) for skeletal regenerative medicine.
  • To explore cell-based therapy approaches for preventing OA and OP onset.
  • To identify innovative therapeutic targets using miRNAs for skeletal repair.

Main Methods:

  • Literature review of studies combining stem cells and miRNAs for skeletal regeneration.
  • Analysis of miRNA involvement in chondrogenic differentiation and bone formation.
  • Evaluation of in vivo evidence for stem cell-miRNA therapies in cartilage and bone repair.

Main Results:

  • The combination of stem cells and miRNAs has demonstrated success in regenerating bone and cartilage in vivo.
  • Specific miRNAs, such as miR-146b, are implicated in chondrogenic differentiation and hold potential for therapeutic targeting.
  • Stem cell-miRNA therapies show promise for repairing articular cartilage defects and treating osteoporosis.

Conclusions:

  • Combining skeletal stem cells (SSCs) with specific microRNAs (miRNAs) presents a viable cell-based therapy strategy for skeletal regenerative medicine.
  • This approach offers innovative therapeutic avenues for osteoarthritis and osteoporosis.
  • Further research into candidate miRNAs and SSCs can advance skeletal repair and disease prevention.
Keywords:
BoneCartilageOsteoarthritisOsteoporosisSkeletal stem cellmiRNA

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