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Microfluidic systems for studying dynamic function of adipocytes and adipose tissue
Xiangpeng Li1, Christopher J Easley2
1Department of Chemistry and Biochemistry, Auburn University, Auburn, AL, 36849, USA.
Analytical and Bioanalytical Chemistry
|December 8, 2017
Summary
Microfluidic organ-on-a-chip technology is advancing the study of adipose tissue (fat). These systems mimic the fat microenvironment, offering new insights into metabolic diseases like obesity and diabetes.
Area of Science:
- Biomedical Engineering
- Cell Biology
- Endocrinology
Background:
- Adipose tissue, once viewed solely for energy storage, is now recognized as a crucial endocrine organ involved in hormonal regulation.
- Dysfunctional adipose tissue is central to metabolic disorders such as obesity, diabetes, and metabolic syndrome.
- Studying dynamic adipocyte and adipose tissue function has been historically challenging.
Purpose of the Study:
- To review recent advancements in microfluidic systems for adipose tissue culture and analysis.
- To highlight the potential of microfluidics in creating in vitro platforms for studying biological systems.
- To discuss the current state and future prospects of microfluidic adipose tissue models.
Main Methods:
- Focuses on a critical review of existing literature on microfluidic applications for adipose tissue.
- Examines organ-on-a-chip technologies and their relevance to mimicking the adipose microenvironment.
- Analyzes methods for culturing and interrogating adipocytes and adipose tissue in microfluidic devices.
Main Results:
- Significant progress has been made in developing microfluidic devices for dynamic adipose tissue studies.
- Microfluidic platforms offer enhanced control over the cellular microenvironment for adipocytes.
- These systems are beginning to provide novel insights into adipocyte function.
Conclusions:
- Microfluidic technology for adipose tissue research is an emerging field with immense potential.
- These advanced in vitro models are expected to deepen our understanding of adipose tissue physiology and pathology.
- Future microfluidic systems will likely offer sophisticated mimicry of the adipose microenvironment, aiding in the study of normal and diseased states.
