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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Feb 17, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Endophthalmitis: Then and Now.

Nidhi Relhan1, Richard K Forster1, Harry W Flynn1

  • 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

American Journal of Ophthalmology
|December 9, 2017
PubMed
Summary
This summary is machine-generated.

Strategies for preventing and managing endophthalmitis have evolved over 100 years. Current intravitreal antimicrobial approaches offer improved visual outcomes for this sight-threatening condition.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Medical History

Background:

  • Endophthalmitis remains a significant cause of vision loss.
  • Understanding its historical management is crucial for current practice.

Purpose of the Study:

  • To review the evolution of endophthalmitis prevention and management strategies over the last century.
  • To provide a perspective on current trends and approaches.

Main Methods:

  • Author-selected review of historical studies.
  • Analysis of changes in endophthalmitis management strategies over 100 years.

Main Results:

  • Three distinct eras of endophthalmitis management are identified: pre-antimicrobial, systemic antimicrobial, and intravitreal antimicrobial.
  • Management strategies vary based on etiology (endogenous, post-surgical, etc.).
  • Pars plana vitrectomy is typically reserved for advanced cases.

Conclusions:

  • Despite advances, endophthalmitis remains a sight-threatening complication.
  • Timely management with appropriate antimicrobials is key to optimizing visual outcomes.