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Updated: Feb 17, 2026

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
Published on: October 18, 2024
14-3-3 proteins: an important regulator of autophagy in diseases
Haoyuan Jia1,2, Zhaofeng Liang1, Xu Zhang1
1Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu UniversityZhenjiang, Jiangsu, P. R. China.
Abstract:
Autophagy is a cell digestion process that determines cell fate by promoting cell survival or inducing cell death in a cell context-dependent manner. Several classical signaling pathways, such as phosphoinositide-3-kinase and mammalian target of rapamycin, tightly regulate autophagy. 14-3-3 proteins regulate various signaling pathways by phosphorylation-dependent binding with partner proteins. 14-3-3 proteins also regulate autophagy by binding with autophagy-related proteins such as Beclin-1 and hVPS34. This review summarizes the role of 14-3-3 proteins in the control of autophagy in cancer, neurodegenerative diseases and other pathological conditions.
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