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Preparation of DNA-crosslinked Polyacrylamide Hydrogels
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pH-responsive and switchable triplex-based DNA hydrogels.

Jiangtao Ren1, Yuwei Hu1, Chun-Hua Lu1

  • 1Institute of Chemistry and the Center for Nanoscience and Nanotechnology , The Hebrew University of Jerusalem , Jerusalem 91904 , Israel .

Chemical Science
|December 9, 2017
PubMed
Summary
This summary is machine-generated.

New DNA hydrogels respond to pH changes, forming and dissolving reversibly. These materials can encapsulate and release anti-cancer drugs like coralyne, offering potential for targeted drug delivery systems.

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Area of Science:

  • Biomaterials Science
  • Supramolecular Chemistry
  • Drug Delivery Systems

Background:

  • Developing smart materials that respond to environmental stimuli is crucial for advanced applications.
  • DNA-based hydrogels offer unique properties due to DNA's programmability and biocompatibility.
  • pH-responsive materials are essential for controlled release applications, particularly in biological systems.

Purpose of the Study:

  • To develop novel, reversible pH-responsive DNA hydrogels utilizing Hoogsteen triplex structures.
  • To investigate the hydrogel formation and dissolution mechanisms triggered by specific pH values.
  • To explore the potential of these DNA hydrogels as carriers for anti-cancer drug delivery.

Main Methods:

  • Design and synthesis of DNA hydrogels crosslinked via Hoogsteen triplexes (CG·C+ and TA·T).
  • Characterization of hydrogel properties and pH-responsive transitions (hydrogel to solution and vice versa).
  • Investigation of drug (coralyne) binding and pH-controlled release from the TA·T triplex hydrogel.

Main Results:

  • Two distinct pH-responsive DNA hydrogel systems were successfully prepared based on Hoogsteen triplexes.
  • System 1: Duplex DNA bridges dissolve at pH 5.0 via CG·C+ triplex formation; stable at pH 7.4.
  • System 2: TA·T triplex crosslinks dissociate at pH 10.0, leading to hydrogel liquefaction; stable at pH 7.0.
  • Reversible, cyclic hydrogel/solution transitions were achieved by modulating pH.
  • Anti-cancer drug coralyne specifically binds to TA·T triplex hydrogels, increasing stiffness.
  • Controlled release of coralyne from the hydrogel was demonstrated, dependent on pH changes.

Conclusions:

  • Novel reversible pH-responsive DNA hydrogels based on Hoogsteen triplexes have been engineered.
  • These hydrogels exhibit tunable sol-gel transitions in response to specific pH stimuli.
  • The TA·T triplex hydrogel shows promise for targeted delivery and pH-controlled release of anti-cancer drugs.