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Related Concept Videos

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Amyloid Fibrils03:03

Amyloid Fibrils

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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Amyloid Fibrils03:03

Amyloid Fibrils

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Related Experiment Video

Updated: Feb 17, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
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The dementia syndromes.

Mary E O'Brien

    Postgraduate Medicine
    |December 9, 2017
    PubMed
    Summary

    Dementia significantly impacts the elderly, with aging as a primary risk factor. Primary care physicians play a crucial role in managing this growing public health challenge.

    Area of Science:

    • Geriatrics
    • Neurology
    • Public Health

    Background:

    • Dementia is a devastating illness affecting the elderly, characterized by progressive cognitive decline.
    • The aging population worldwide is leading to an increased prevalence of dementia.
    • This disorder imposes a substantial burden on families, healthcare systems, and communities.

    Purpose of the Study:

    • To explore the role of primary care physicians in addressing the challenges posed by dementia.
    • To identify strategies for primary care to mitigate the impact of dementia on patients and society.

    Main Methods:

    • This study involves a review of current literature and clinical guidelines.
    • Analysis of the primary care physician's position in early detection and management.

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    Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
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    Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

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  • Exploration of care coordination and patient support strategies.

    • Main Results:

    • Primary care physicians are pivotal in the early identification and diagnosis of dementia.
    • Effective management in primary care can improve patient quality of life and reduce caregiver burden.
    • Interdisciplinary collaboration is essential for comprehensive dementia care.

    Conclusions:

    • Primary care physicians are essential in the fight against dementia.
    • Enhanced primary care strategies can significantly alleviate the impact of dementia.
    • Proactive management by primary care is key to addressing the increasing prevalence of dementia.