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Related Concept Videos

Histone Modification02:32

Histone Modification

16.3K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Histone Modification02:32

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Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Related Experiment Video

Updated: Feb 17, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

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SnapShot: Lysine Methylation beyond Histones.

Kyle K Biggar1, Zhentian Wang2, Shawn S-C Li3

  • 1Institute of Biochemistry, Carleton University, Ottawa, ON, Canada; Department of Biochemistry, Western University, London, ON, Canada.

Molecular Cell
|December 9, 2017
PubMed
Summary

Lysine methylation, a key protein regulator, is vital for cellular functions. Research now explores its broader role beyond histones, revealing dynamic impacts on non-histone proteins.

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Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli
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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Proteomics

Background:

  • Lysine methylation is a crucial post-translational modification (PTM) regulating protein function.
  • While extensively studied in histones and chromatin, the broader methyllysine proteome is largely unexplored.

Purpose of the Study:

  • To provide an overview of current lysine methylation research.
  • To highlight the dynamic nature of lysine methylation on both histone and non-histone proteins.

Main Methods:

  • Literature review and synthesis of existing research on lysine methylation.
  • Analysis of studies focusing on histone and non-histone protein methylation.

Main Results:

  • Lysine methylation is a dynamic and reversible PTM.
  • Significant research exists on histone methylation, but non-histone protein methylation is an emerging field.

Conclusions:

  • Lysine methylation extends beyond histones, impacting diverse cellular processes.
  • Further investigation into the non-histone methyllysine proteome is warranted to understand its full functional significance.