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mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance

Samantha Haller1, Subir Kapuria2, Rebeccah R Riley2

  • 1Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA; Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Cell Stem Cell
|December 9, 2017
PubMed
Summary

Target of rapamycin (TOR) signaling drives stem cell loss during repeated tissue regeneration. Inhibiting mammalian target of rapamycin complex 1 (mTORC1) prevents age-related stem cell decline, revealing its conserved role in aging.

Keywords:
DrosophilaagingintestinemTORmetabolismmusclerapamycinregenerationsomatic stem celltrachea

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