Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coupling light from laser to NANF with a hyperbolic profile fiber microlens.

Optics express·2026
Same author

Cataract surgery in a simulated operating room environment: a pilot study.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026
Same author

High-Q aluminum oxide microring resonators operating at 460 nm.

Optics express·2025
Same author

Polymer-Based Microstructured Photonic Membrane for Passive Heating Textiles.

ACS omega·2025
Same author

Liquid and gas mid-infrared integrated spectroscopic sensor.

Optics express·2025
Same author

Neurodevelopmental impacts of betamethasone administered in the late preterm period: An experimental study in CD-1 mice.

Neurotoxicology and teratology·2025

Related Experiment Video

Updated: Feb 17, 2026

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

8.5K

High sensitivity optical biosensor based on polymer materials and using the Vernier effect.

Paul Azuelos, Pauline Girault, Nathalie Lorrain

    Optics Express
    |December 10, 2017
    PubMed
    Summary

    We developed a polymer optical biosensor using photolithography. This Vernier effect sensor achieves high sensitivity for detecting glucose concentration changes via refractive index variations.

    More Related Videos

    Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
    09:23

    Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

    Published on: December 13, 2017

    6.7K
    Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
    10:59

    Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

    Published on: February 10, 2014

    10.7K

    Related Experiment Videos

    Last Updated: Feb 17, 2026

    A Polyaniline-based Sensor of Nucleic Acids
    07:58

    A Polyaniline-based Sensor of Nucleic Acids

    Published on: November 1, 2016

    8.5K
    Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
    09:23

    Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

    Published on: December 13, 2017

    6.7K
    Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
    10:59

    Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

    Published on: February 10, 2014

    10.7K

    Area of Science:

    • Polymer optics
    • Optical biosensing
    • Nanophotonics

    Background:

    • Mach-Zehnder interferometers are widely used for sensing applications.
    • Polymer optical waveguides offer advantages in fabrication and cost-effectiveness.
    • The Vernier effect can enhance the sensitivity of interferometric sensors.

    Purpose of the Study:

    • To fabricate a novel polymer optical biosensor utilizing the Vernier effect.
    • To achieve high homogeneous sensitivity for refractive index measurements.
    • To demonstrate the sensor's capability in detecting glucose solutions.

    Main Methods:

    • Fabrication of a SU8/PMATRIFE polymer optical biosensor using standard photolithography.
    • Integration of micro-resonators on each arm of a Mach-Zehnder interferometer.
    • Measurement of the sensor's response to varying glucose concentrations based on refractive index changes.

    Main Results:

    • The fabricated sensor exhibited high homogeneous sensitivity.
    • Sensitivity was measured to be 17558 nm/RIU.
    • A low limit of detection was achieved, estimated at 1.1 x 10-6 RIU.

    Conclusions:

    • The Vernier effect polymer optical biosensor demonstrates excellent performance for refractive index sensing.
    • The developed sensor is suitable for high-sensitivity glucose concentration detection.
    • Standard photolithography provides a viable method for fabricating such advanced optical biosensors.