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Biomarkers in connective tissue diseases.
Neelakshi R Jog1, Judith A James2
1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Okla.
The Journal of Allergy and Clinical Immunology
|December 10, 2017
Summary
Biomarkers, including autoantibodies, are crucial for diagnosing and managing autoimmune connective tissue diseases like lupus and rheumatoid arthritis. New biomarkers and personalized approaches improve disease monitoring and treatment selection.
Area of Science:
- Rheumatology
- Immunology
- Clinical Diagnostics
Background:
- Autoimmune connective tissue diseases (ACTDs) exhibit significant clinical variability, necessitating reliable biomarkers.
- Current biomarkers, such as autoantibodies and soluble mediators, correlate with clinical features and disease progression.
- Limited biomarker specificity exists due to disease overlap, highlighting the need for improved diagnostic and prognostic tools.
Purpose of the Study:
- To review current biomarkers for major systemic autoimmune connective tissue disorders.
- To discuss newly proposed biomarkers for disease onset and progression.
- To explore novel approaches for personalized monitoring and treatment in ACTDs.
Main Methods:
- Literature review of existing and emerging biomarkers.
- Analysis of biomarker utility in systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and anti-neutrophil cytoplasmic antibody-associated vasculitides.
- Discussion of innovative strategies for patient stratification and personalized medicine.
Main Results:
- Established biomarkers aid in diagnosis and treatment selection for key ACTDs.
- Emerging biomarkers show promise for earlier detection and tracking of disease stages.
- Personalized approaches are being developed to address patient heterogeneity.
Conclusions:
- Biomarkers are essential for comprehensive management of autoimmune connective tissue diseases.
- Continued research into novel biomarkers and personalized strategies will enhance patient outcomes.
- Addressing biomarker limitations is key to advancing the care of patients with ACTDs.
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