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S Barbarot1, H Aubert1

  • 1Service de dermatologie, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France.

Annales De Dermatologie Et De Venereologie
|December 10, 2017
PubMed
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Atopic dermatitis involves genetic and environmental factors impacting the skin barrier and immune system. Altered skin and gut microbiome diversity, influenced by environmental factors, plays a key role in developing atopy.

Area of Science:

  • Dermatology
  • Immunology
  • Microbiome research

Background:

  • Atopic dermatitis (AD) is a complex skin condition with genetic and environmental origins.
  • Key factors include skin barrier dysfunction, genetic predispositions in immunity, and microbiome alterations.

Purpose of the Study:

  • To elucidate the multifactorial pathophysiology of atopic dermatitis.
  • To highlight the interplay between genetic, environmental, and microbiome factors in AD development.

Main Methods:

  • Review of existing literature on atopic dermatitis.
  • Analysis of genetic factors, including filaggrin mutations.
  • Examination of the role of skin and gut microbiomes.

Main Results:

Keywords:
Atopic dermatitsDermatite atopiqueMicrobiome cutanéPathophysiologyPhysiopathologieSkin microbiota

Related Experiment Videos

  • Skin barrier abnormalities, often due to filaggrin gene mutations, are implicated.
  • Genes related to innate and adaptive immunity contribute to AD.
  • Environmental factors disrupt microbiome diversity, influencing atopy development.

Conclusions:

  • Atopic dermatitis pathogenesis is multifactorial, involving genetic and environmental influences.
  • The hygiene hypothesis is supported by evidence linking microbiome diversity to atopy.
  • Understanding these factors is crucial for managing atopic dermatitis.