Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurotransmitters01:31

Neurotransmitters

2.9K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
2.9K
Neurotransmitters01:30

Neurotransmitters

5.2K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
5.2K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

86.8K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
86.8K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.8K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.8K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

2.3K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.3K
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

13.4K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
13.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy.

Progress in brain research·2021
Same author

Corrigendum: An Inflammation-Centric View of Neurological Disease: Beyond the Neuron.

Frontiers in cellular neuroscience·2020
Same author

Oligodendrocyte precursor cells as a therapeutic target for demyelinating diseases.

Progress in brain research·2019
Same author

Neuroepigenetics and Alzheimer's Disease: An Update.

Journal of Alzheimer's disease : JAD·2018
Same author

Conference Report: 184th American Association for the Advancement of Science Annual Meeting, Austin TX, USA Feb. 15-19, 2018.

CNS & neurological disorders drug targets·2018
Same author

Serum amyloid A primes microglia for ATP-dependent interleukin-1β release.

Journal of neuroinflammation·2018

Related Experiment Video

Updated: Feb 17, 2026

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
13:46

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

Published on: July 11, 2020

6.3K

Neurotrophic Factors: An Overview.

Stephen D Skaper1

  • 1Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy. stephen.skaper@unipd.it.

Methods in Molecular Biology (Clifton, N.J.)
|December 10, 2017
PubMed
Summary

Neurotrophins are crucial proteins supporting neuron survival and function throughout life. They signal through tropomyosin-related kinase (Trk) and p75 neurotrophin receptors (p75NTR) to regulate neuronal development and adult plasticity.

Keywords:
Brain-derived growth factorGlial cell line-derived neurotrophic factorInflammationNerve growth factorNeuroregenerationNeurotrophic factorsNeurotrophin 4Neurotrophin-3PainReceptor tyrosine kinasesTropomyosin-related kinase (Trk)

More Related Videos

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons
10:53

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons

Published on: September 15, 2014

15.8K
Protocol for Culturing Sympathetic Neurons from Rat Superior Cervical Ganglia SCG
11:49

Protocol for Culturing Sympathetic Neurons from Rat Superior Cervical Ganglia SCG

Published on: January 30, 2009

24.0K

Related Experiment Videos

Last Updated: Feb 17, 2026

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
13:46

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

Published on: July 11, 2020

6.3K
Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons
10:53

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons

Published on: September 15, 2014

15.8K
Protocol for Culturing Sympathetic Neurons from Rat Superior Cervical Ganglia SCG
11:49

Protocol for Culturing Sympathetic Neurons from Rat Superior Cervical Ganglia SCG

Published on: January 30, 2009

24.0K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Neurotrophins are essential proteins regulating neuronal survival, development, and function in the central and peripheral nervous systems.
  • Their limited availability during development precisely controls neuronal populations and target innervation density.

Purpose of the Study:

  • To provide a comprehensive overview of neurotrophin biology.
  • To detail the receptors and intracellular signaling pathways utilized by neurotrophins.

Main Methods:

  • Review of existing literature on neurotrophin function, receptors, and signaling.
  • Analysis of the roles of tropomyosin-related kinase (Trk) receptors (TrkA, TrkB, TrkC) and p75 neurotrophin receptor (p75NTR).

Main Results:

  • Neurotrophins mediate biological effects via Trk receptors and p75NTR.
  • Trk receptor activation initiates downstream signaling cascades including Ras, PI3K, PLC-γ1, and MAPK pathways.
  • Neurotrophins are vital for synaptic function, plasticity, and neuronal maintenance in adulthood.

Conclusions:

  • Neurotrophins are critical for neuronal development and adult homeostasis.
  • Understanding neurotrophin signaling pathways is key to comprehending neuronal health and disease.