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Astrocyte/Microglia Cocultures as a Model to Study Neuroinflammation
Laura Facci1, Massimo Barbierato1, Stephen D Skaper2
1Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.
Methods in Molecular Biology (Clifton, N.J.)
|December 10, 2017
Abstract:
Glial cell activation plays an important role in the pathogenesis of various neurodegenerative disorders as well as in chronic and neuropathic pain. This chapter describes a model which allows one to assess the individual and combined contributions of astrocytes and microglia in response to a pro-inflammatory stimulus, with emphasis on ionotropic purinergic receptors.
