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Middle Cerebral Artery Occlusion by an Intraluminal Suture Method
Rosalia Crupi1, Rosanna Di Paola1, Emanuela Esposito1
1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Methods in Molecular Biology (Clifton, N.J.)
|December 10, 2017
Summary
This study details the intraluminal monofilament model for middle cerebral artery (MCA) occlusion in rodents. This method effectively simulates stroke conditions for developing new therapeutic approaches.
Area of Science:
- Neurology
- Experimental Medicine
- Neuroscience
Background:
- Stroke is a leading cause of death and disability globally.
- Limited therapeutic options exist for ischemic stroke.
- Rodent models are crucial for developing novel stroke treatments.
Purpose of the Study:
- To describe the intraluminal monofilament model of middle cerebral artery (MCA) occlusion.
- To highlight its advantages for studying focal cerebral ischemia.
- To assess its relevance for stroke research and therapeutic development.
Main Methods:
- The intraluminal monofilament model involves inserting a filament into the external carotid artery.
- The filament is advanced into the internal carotid artery to occlude the MCA.
- This technique models both permanent and transient MCA occlusions without requiring craniectomy.
Main Results:
- The model successfully induces infarction in the MCA territory.
- It allows for both permanent and transient occlusion studies.
- Avoidance of craniectomy preserves intracranial pressure and temperature.
Conclusions:
- The intraluminal monofilament MCA occlusion model is a valuable tool for stroke research.
- Its advantages include ease of use and minimal invasiveness.
- The model's relevance is enhanced by its mimicry of mechanical thrombectomy conditions.
