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Updated: Jan 31, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Cryptococcal meningitis in apparently immunocompetent patients: association with idiopathic CD4+ lymphopenia
Samuel Shribman1, Alastair Noyce2, Sharmilee Gnanapavan3
1Department of Neurology, St George's Hospital, London, UK.
Abstract:
We present two cases of cryptococcal meningitis in people subsequently diagnosed with idiopathic CD4+ lymphopenia. Both presented with new onset headaches without sinister features and were sent home on multiple occasions from emergency departments. Cryptococcal meningitis in HIV-negative patients poses major diagnostic and management problems; the associated mortality is 9%-27%. We suggest performing blood and cerebrospinal fluid cryptococcal antigen tests in all people with lymphocytic meningitis.
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