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Updated: Feb 17, 2026

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
Published on: January 23, 2018
Structured Spontaneity: Building Circuits in the Human Prenatal Brain
1Merrill Palmer Skillman Institute for Child and Family Development, Wayne State University, Detroit, MI 48202, USA; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48202, USA; Perinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI 48201, USA.
Abstract:
Early brain activity is crucial for neurogenesis and the development of brain networks. However, it has been challenging to localize regions in the developing human brain that contribute to spontaneous waves of neuronal activity. Recently, Arichi and colleagues reported that the temporal and heteromodal insular cortices have a central role in propagating these neural instructional signals.
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