Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epilepsy and Seizures: Overview

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rational design and in vivo validation of capsid inhibitors for enterovirus D68.

Nature communications·2026

Same author

Implementation and outcomes of a rapid response genomic hospital epidemiology programme at an academic medical centre over 7 years.

The Lancet. Microbe·2026

Same author

Annual Report from the Editor-in-Chief (2025).

Annals of neurology·2025

Same author

Oral Cephalexin Population Pharmacokinetics and Target Attainment Analysis in Infants 7-60 Days Old.

Journal of the Pediatric Infectious Diseases Society·2025

Same author

Dynamics of endemic virus re-emergence in children in the USA following the COVID-19 pandemic (2022-23): a prospective, multicentre, longitudinal, immunoepidemiological surveillance study.

The Lancet. Infectious diseases·2025

Same author

Using COVID-19 pandemic perturbation to model RSV-hMPV interactions and potential implications under RSV interventions.

Nature communications·2025

Same journal

Prevention and Control of Clostridioides difficile Infection for the Infectious Diseases Clinician.

Infectious disease clinics of North America·2026

Same journal

Infection Control Strategies to Prevent Emergence and Transmission of Resistant Gram-Negative Bacteria.

Infectious disease clinics of North America·2026

Same journal

Preventing the Spread of Tuberculosis in Health Care Settings.

Infectious disease clinics of North America·2026

Same journal

Threats to Success: Principles of Infection Prevention and Control in Health Care Settings, Part 2: Device and Pathogen Management.

Infectious disease clinics of North America·2026

Same journal

Ventilator-Associated Events: Surveillance and Prevention.

Infectious disease clinics of North America·2026

Same journal

Nosocomial Fungal Infections: Epidemiology, Control Strategies, and Prevention of Candida and Other Yeasts.

Infectious disease clinics of North America·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 17, 2026

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Published on: September 23, 2022

Encephalitis in US Children.

Kevin Messacar¹, Marc Fischer², Samuel R Dominguez¹

¹Department of Pediatrics, University of Colorado, Children's Hospital Colorado, B055, 13123 East 16th Avenue, Aurora, CO 80045, USA.

Infectious Disease Clinics of North America

|December 12, 2017

Summary

This summary is machine-generated.

Encephalitis is a severe brain inflammation affecting children. Prompt diagnosis and treatment are crucial, though infectious causes are found in less than half of cases.

Keywords:

Anti-NMDA Arbovirus Encephalitis Enterovirus Herpes simplex virus Meningoencephalitis Myelitis

More Related Videos

In Vivo Imaging Systems IVIS Detection of a Neuro-Invasive Encephalitic Virus

In Vivo Imaging Systems IVIS Detection of a Neuro-Invasive Encephalitic Virus

Published on: December 2, 2012

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Related Experiment Videos

Last Updated: Feb 17, 2026

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Published on: September 23, 2022

In Vivo Imaging Systems IVIS Detection of a Neuro-Invasive Encephalitic Virus

In Vivo Imaging Systems IVIS Detection of a Neuro-Invasive Encephalitic Virus

Published on: December 2, 2012

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Area of Science:

Pediatric Neurology
Infectious Diseases
Neuroinflammation

Background:

Encephalitis presents as neurologic dysfunction due to central nervous system inflammation.
It is an uncommon but severe condition, particularly in children.
Timely diagnosis and management are critical for patient outcomes.

Purpose of the Study:

To outline the recommended approach for managing pediatric encephalitis.
To emphasize the importance of diagnostic evaluation for treatable causes.
To highlight the diagnostic challenges and potential non-infectious etiologies.

Main Methods:

Supportive care and empiric therapies for common causes.
Prioritization of diagnostic evaluation for high-risk conditions.
Comprehensive diagnostic workup for encephalitis in children.

Main Results:

An infectious etiology is identified in fewer than 50% of pediatric encephalitis cases.
Diagnostic yield of extensive workups remains limited.
Non-infectious or post-infectious causes are frequently implicated.

Conclusions:

Pediatric encephalitis requires a multi-faceted management strategy.
The diagnostic evaluation should balance empiric treatment with thorough investigation.
Non-infectious processes should be considered when infectious causes are not identified.