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Related Experiment Video

Updated: Feb 17, 2026

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Single Fraction Stereotactic Ablative Body Radiotherapy for Oligometastasis: Outcomes from 132 Consecutive Patients.

S Gandhidasan1, D Ball1, T Kron1

  • 1Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Australia.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|December 12, 2017
PubMed
Summary

Single fraction stereotactic ablative body radiotherapy (SABR) shows promise for oligometastases, achieving high rates of freedom from widespread disease and local control with minimal toxicity.

Keywords:
OligometastasesSABRradiotherapysingle fractionstereotactic

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Stereotactic ablative body radiotherapy (SABR) is a treatment for oligometastases.
  • The optimal dose and fractionation for SABR remain undetermined.
  • This study investigates outcomes of single-fraction SABR for oligometastatic disease.

Purpose of the Study:

  • To evaluate the efficacy and safety of single-fraction SABR in patients with oligometastatic disease.
  • To assess freedom from widespread disease and local progression rates.
  • To determine treatment-related toxicity.

Main Methods:

  • Retrospective review of 132 patients treated with single-fraction SABR for 1-3 oligometastases (2010-2015).
  • Primary outcome: freedom from widespread disease (distant recurrence or >=4 metastases).
  • Secondary outcomes: local progression and toxicity.

Main Results:

  • 186 treatments were delivered, most commonly to lung (51%) and bone (40%) sites.
  • Genitourinary malignancy was most frequent (46 patients).
  • 1-year freedom from widespread disease was 75%; 2-year was 52%. 1-year local progression-free survival was 90%; 2-year was 84%. Lumbar vertebral compression fracture was the sole grade 3+ toxicity.

Conclusions:

  • Single-fraction SABR demonstrates high rates of freedom from widespread disease.
  • Favorable local control is achieved with single-fraction SABR.
  • Toxicity profile is low and comparable to multi-fraction SABR.