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Trousseau's Syndrome Causing Refractory Deep Venous Thrombosis
Shoko Mizoguchi1, Toshiki Sawai1, Atsuya Hirota1
1Department of Cardiology, Mie Prefectural General Medical Center, Japan.
Internal Medicine (Tokyo, Japan)
|December 12, 2017
Summary
Trousseau's syndrome, a rare condition linking cancer and blood clots, can cause worsening deep venous thrombosis (DVT) despite standard treatment. Effective management involves heparin and treating the underlying cancer.
Area of Science:
- Oncology
- Hematology
- Vascular Medicine
Background:
- Deep venous thrombosis (DVT) is a serious condition often managed with anticoagulants like vitamin K antagonists (VKAs).
- Inferior vena cava (IVC) filters are used in select DVT cases to prevent pulmonary embolism.
- Refractory DVT cases require thorough investigation for underlying causes.
Observation:
- A 66-year-old male with a history of DVT, VKA treatment, and IVC filter experienced DVT exacerbation.
- Despite re-administration of VKA, the patient's DVT progressed, prompting further investigation.
- Colon cancer was diagnosed, leading to a diagnosis of Trousseau's syndrome.
Findings:
- Trousseau's syndrome, characterized by migratory thrombophlebitis, was identified as the cause of refractory DVT.
- Administration of heparin and surgical resection of the colon tumors resulted in thrombi regression.
- This case highlights the critical link between malignancy and venous thromboembolism.
Implications:
- Trousseau's syndrome must be considered in patients with unexplained or refractory venous thrombosis.
- Integrated treatment involving anticoagulation (heparin) and oncological management is crucial for Trousseau's syndrome.
- Early cancer detection and treatment can lead to resolution of associated thrombotic events.
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