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Updated: Feb 17, 2026

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Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
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Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS-ERG fusion gene
Yusuke Toda1, Yuya Nagai1, Daiki Shimomura2
1Department of Hematology Tenri Hospital Tenri Nara Japan.
Clinical Case Reports
|December 12, 2017
Abstract:
We herein report a rare case of acute basophilic leukemia with t(16;21)(p11;q22) generating the FUS-ERG fusion gene. The basophilic nature of leukemia blasts was demonstrated by cytomorphology, toluidine blue metachromasia, mature basophil-associated antigen expression, and characteristic granules under electron microscopy. The molecular link between t(16;21)/FUS-ERG and basophilic differentiation remains unclear.

