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Updated: Feb 17, 2026
07:06
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
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Early Rescue from Acute Severe Clostridium Difficile: A Novel Treatment Strategy.
Biniam Kidane1, Kalvin Lung1, Greig McCreery1
11 Division of General Surgery, Western University , London, Ontario, Canada .
Surgical Infections
|December 12, 2017
Summary
Bedside gastrointestinal lavage (GIL) offers a safe, non-operative approach for severe Clostridium difficile infections (CDI) when conventional therapy fails. This novel treatment showed comparable safety and outcomes to colectomy, reducing surgical risks for CDI patients.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Surgical Innovation
Background:
- Severe Clostridium difficile infections (CDI) present significant treatment challenges.
- A novel bedside gastrointestinal lavage (GIL) protocol was developed for severe, complicated CDI.
- This study evaluates early outcomes of non-operative bedside GIL against colectomy.
Purpose of the Study:
- To describe the development and early outcomes of bedside GIL for severe, complicated CDI.
- To compare the safety and efficacy of bedside GIL with colectomy in managing severe CDI.
Main Methods:
- Retrospective cohort study of patients with severe, complicated CDI who failed conventional therapy.
- Comparison between patients treated with bedside GIL (n=19) and those undergoing colectomy (n=17).
- GIL involved nasojejunal tube insertion and 8L polyethylene glycol lavage over 48 hours, alongside standard antibiotics.
Main Results:
- No significant demographic or clinical differences between GIL and colectomy groups.
- In-hospital mortality was 26% for GIL versus 41% for colectomy (p=0.35).
- Only one patient in the GIL group required colectomy; complication rates were similar between groups.
Conclusions:
- Bedside GIL appears safe for severe, complicated CDI refractory to medical therapy.
- GIL did not increase morbidity or mortality risk compared to colectomy.
- Non-operative bedside GIL is a viable alternative to colectomy for select CDI patients.
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