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Drug-eluting balloon: design, technology and clinical aspects
Meenasree Bukka1, Poorna Jyothi Rednam1, Mukty Sinha1
1Department of Medical Devices, National Institute of Pharmaceutical Education and Research, Ahmedabad (NIPER-A) Palaj, Opp. Air Force Station, Gandhinagar-382355, Gujarat, India.
Biomedical Materials (Bristol, England)
|December 12, 2017
Summary
Drug-eluting balloons offer a stent-free approach to treating vascular conditions like atherosclerosis by delivering anti-proliferative drugs. This technology promotes vessel healing and reduces restenosis without permanent implants.
Area of Science:
- Vascular Medicine
- Biomaterials Science
- Interventional Cardiology
Background:
- Drug-eluting balloons (DEBs) are non-stent technologies for vascular repair.
- They deliver anti-proliferative drugs to the vessel wall via an inflated balloon.
- This approach aims to restore luminal vascularity and prevent complications without foreign body implantation.
Purpose of the Study:
- To review the evolution and rationale behind drug-eluting balloon technology.
- To critically analyze and compare currently marketed DEB technologies.
- To provide insight into different coating techniques, drug choices, and release patterns.
Main Methods:
- Literature review of drug-eluting balloon devices.
- Analysis of coating techniques and drug delivery mechanisms.
- Technical comparison of available DEB products.
Main Results:
- Several DEB devices are in clinical use, including DIOR®, PACCOCATH®, SeQuent®Please, and IN.PACT™.
- Devices differ in balloon material, coating methods, drug selection, and drug release kinetics.
- The review analyzes various coating strategies and provides a technical comparison of DEB technologies.
Conclusions:
- Drug-eluting balloons represent an evolving stent-free treatment option for vascular diseases.
- Targeted drug delivery by DEBs aids in rapid vessel healing and inhibits smooth muscle cell proliferation.
- Understanding the technical variations in DEBs is crucial for optimizing treatment outcomes.
