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Small Bioactive Peptides for Biomaterials Design and Therapeutics
1Department of Chemistry, University of Reading, Whiteknights , Reading RG6 6AD, United Kingdom.
Chemical Reviews
|December 12, 2017
Summary
This review surveys bioactive peptide sequences essential for biomaterials and therapeutics. It details peptides for cell adhesion, drug delivery, and antimicrobial applications, offering a key resource for peptide-based innovations.
Area of Science:
- Biochemistry
- Materials Science
- Pharmacology
Background:
- Short bioactive peptides are crucial in biological systems.
- Diverse applications exist for peptides, from biomaterials to therapeutics.
- A comprehensive summary of key peptide sequences is needed.
Purpose of the Study:
- To provide a concise and extensive survey of short bioactive peptide sequences.
- To cover peptides with applications in biomaterials development and therapeutic uses.
- To serve as a convenient resource for researchers and developers.
Main Methods:
- Literature review of scientific databases.
- Categorization of bioactive peptides based on function and application.
- Synthesis of information on sequence utility and significance.
Main Results:
- Identified and categorized key peptide sequences for various applications.
- Highlighted peptides for cell adhesion, structural roles, and drug delivery (e.g., cell-penetrating and tumor-homing peptides).
- Included antimicrobial peptides, peptide hormones, growth factors, neuropeptides, amyloid peptides, antioxidant peptides, and anticancer peptides.
Conclusions:
- Bioactive peptide sequences are versatile and critical for advancing biomaterials and therapeutics.
- This review consolidates essential peptide information, facilitating research and development.
- The summarized sequences offer significant utility for novel peptide-based drugs and materials.
