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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Microbiota and Aging. A Review and Commentary.

Carmen García-Peña1, Teresa Álvarez-Cisneros1, Ricardo Quiroz-Baez1

  • 1Dirección de Investigación, Instituto Nacional de Geriatría, Ciudad de México, México.

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|December 13, 2017
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Summary

Aging alters the gut microbiota, decreasing diversity and increasing harmful bacteria, which may impact health and cognitive function. These changes are linked to frailty and diseases like Alzheimer's and Parkinson's.

Keywords:
AgingFrailtyInmunoinflamatory systemMicrobiotaNeurodegeneration

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Area of Science:

  • Microbiology
  • Gerontology
  • Immunology

Background:

  • Aging leads to significant alterations in gut microbiota composition and diversity.
  • Changes in the gut microbiota are associated with reduced immune function and chronic inflammation in the elderly.
  • Factors like diet, environment, and geography influence microbiota composition, impacting the gut-brain axis.

Purpose of the Study:

  • To explore the relationship between aging, microbiota alterations, and geriatric diseases.
  • To investigate the role of microbiota changes in age-related health decline and inflammation.
  • To highlight the importance of oral microbiota in brain health during aging.

Main Methods:

  • Review of current literature on microbiota changes in aging populations.
  • Analysis of studies linking microbial composition to geriatric conditions like Parkinson's, Alzheimer's, and frailty.
  • Examination of the gut-brain axis and oral microbiota's role in aging.

Main Results:

  • Aging is associated with reduced microbial diversity and an increase in enteropathogens.
  • Microbiota dysbiosis is observed in geriatric diseases and linked to frailty.
  • Oral microbiota presents a potential pathway for microbial influence on brain health.

Conclusions:

  • Microbiota plays a crucial role in the aging process and overall health span.
  • Understanding microbiota changes is vital for developing interventions against age-related diseases.
  • Targeting the microbiota may offer new strategies for promoting healthy aging.