Bisphenol A (BPA) and cell signaling pathways.
Masaharu Murata1, Jeong-Hun Kang2
1Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Biotechnology Advances
|December 13, 2017
Summary
Bisphenol A (BPA) is an endocrine disruptor linked to various health issues. This review examines BPA
Area of Science:
- Endocrinology and Toxicology
- Molecular Biology and Cellular Signaling
- Environmental Health Sciences
Background:
- Bisphenol A (BPA) is a widely used industrial chemical and endocrine disruptor.
- BPA exposure is associated with adverse effects on various biological systems.
- Cell signaling pathways are implicated in BPA's toxicological mechanisms.
Purpose of the Study:
- To review and synthesize existing literature on Bisphenol A (BPA).
- To explore the association between BPA and key cell signaling pathways.
- To focus on BPA's role in cancer, reproductive toxicity, immune response, and neurodevelopment.
Main Methods:
- Comprehensive literature search on Bisphenol A (BPA) and cell signaling pathways.
- Analysis of studies investigating BPA's impact on cancer-related pathways.
- Review of research on BPA's effects on reproductive, immune, and nervous system pathways.
Main Results:
- BPA exposure is linked to disruptions in multiple cell signaling pathways.
- Evidence suggests BPA's involvement in carcinogenesis and reproductive toxicity.
- BPA affects inflammatory, immune, and neurodevelopmental signaling pathways.
Conclusions:
- Bisphenol A (BPA) exerts toxic effects through various cell signaling pathways.
- Understanding these pathways is crucial for assessing BPA's health risks.
- Further research is warranted to elucidate BPA's comprehensive impact on human health.
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