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The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy
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The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy

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Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.

Mu He1, Wenlei Ye1, Won-Jing Wang2

  • 1Department of Physiology, University of California, San Francisco, CA 94158.

Proceedings of the National Academy of Sciences of the United States of America
|December 13, 2017
PubMed
Summary

The calcium-activated chloride channel TMEM16A maintains cytoplasmic chloride homeostasis, crucial for cell membrane remodeling during mammalian epithelial development. This chloride regulation impacts phosphoinositide organization and membrane trafficking.

Keywords:
calcium-activated chloride channelepithelial morphogenesismembrane remodelingphosphoinositideprimary cilia

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