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Proteobacteria: A Common Factor in Human Diseases

G Rizzatti1, L R Lopetuso1, G Gibiino1

  • 1Department of Internal Medicine, Gastroenterology Division, Policlinico "A. Gemelli" Hospital, Rome, Italy.

Biomed Research International
|December 13, 2017
PubMed

Insights

Proteobacteria, a gut bacteria group, are increasingly linked to various diseases, both in the gut and elsewhere. Their elevated presence may signal conditions like inflammatory bowel disease and metabolic disorders.

Area of Science:

  • Microbiology
  • Human Health
  • Gut Microbiome Research

Background:

  • The gut microbiota plays a crucial role in host health through mutualistic interactions.
  • Proteobacteria are a dominant phylum within the gut microbiota, including known human pathogens.
  • Recent research has intensified focus on the gut microbiota's role in intestinal diseases.

Purpose of the Study:

  • To review current findings on the involvement of Proteobacteria in intestinal and extraintestinal diseases.
  • To highlight Proteobacteria as a potential microbial signature for various pathological conditions.
  • To explore the link between Proteobacteria and inflammation-associated diseases.

Main Methods:

  • Literature review of recent studies on Proteobacteria and disease.
  • Analysis of data on the abundance of Proteobacteria in different disease states.
  • Synthesis of evidence linking Proteobacteria to metabolic, inflammatory, and lung diseases.

Main Results:

  • An increased abundance of Proteobacteria is observed in several disease conditions.
  • Strong evidence links Proteobacteria to metabolic disorders and inflammatory bowel disease.
  • Emerging, though limited, evidence suggests a role in lung diseases like asthma and COPD.

Conclusions:

  • Proteobacteria are increasingly recognized as significant players in both intestinal and extraintestinal diseases.
  • Elevated Proteobacteria levels may serve as a microbial biomarker for disease.
  • Inflammation is a common underlying factor in diseases associated with Proteobacteria.

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