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Related Experiment Videos

Fasting plasma amino acids in elderly men.

D Rudman1, D E Mattson, A G Feller

  • 1Medical Service, Veterans Administration Medical Center, North Chicago, IL.

The American Journal of Clinical Nutrition
|March 1, 1989
PubMed
Summary

Elderly men, both independent and institutionalized, often have suboptimal essential amino acid intake. This study found lower levels of key amino acids in older adults compared to younger men.

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Area of Science:

  • Gerontology
  • Nutritional Biochemistry
  • Clinical Nutrition

Background:

  • Amino acid profiles are crucial for maintaining health, particularly in aging populations.
  • Nutritional status can decline with age, impacting essential amino acid levels.
  • Dementia and institutionalization may further affect nutrient intake and metabolism in elderly men.

Purpose of the Study:

  • To compare fasting amino acid profiles in healthy young men with those in healthy elderly men, and elderly men with dementia (orally-fed and tube-fed).
  • To identify specific amino acid deficiencies or alterations in different elderly male cohorts.

Main Methods:

  • Fasting blood samples were collected from four groups of men: young healthy (A), elderly healthy (B), elderly with dementia orally-fed (C), and elderly with dementia tube-fed (D).

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  • Amino acid concentrations were analyzed to determine fasting profiles.
  • Statistical analysis was performed to compare amino acid levels and ratios between groups.

    • Main Results:

    • Groups B, C, and D showed significantly lower levels of methionine and branched-chain amino acids compared to group A.
    • Methionine levels were also significantly lower in groups C and D compared to group B.
    • The ratio of essential to nonessential amino acids was significantly lower in elderly groups (B, C, D) than in the young group (A).

    Conclusions:

    • Elderly men, including those living independently and in nursing homes, may have suboptimal intake of essential amino acids.
    • Specific amino acids like methionine and branched-chain amino acids appear to be particularly affected in older age and in individuals with dementia.
    • These findings highlight potential nutritional challenges in elderly populations that warrant further investigation and intervention.