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When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
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MAP kinases nomenclature: Time for curation.

Khaled Moustafa1

  • 1a Conservatoire National des Arts et Métiers , Paris , France.

Plant Signaling & Behavior
|December 13, 2017
PubMed
Summary
This summary is machine-generated.

Confusing nomenclature for Mitogen Activated Protein Kinases (MAPKs) causes redundancy. This study proposes curated terminology for MAP kinase families to improve consistency and reduce confusion in scientific indexing.

Keywords:
Abiotic stressERKJNKMAP kinaseMAPKMAPK signaling pathwaysMAPKKMAPKKKMAPKKKKMPKdata curationdata miningdata redundancygene familygene nomenclaturemitogen activated protein kinaseplant abiotic stress

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Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • Protein nomenclature, particularly for Mitogen Activated Protein Kinases (MAPKs), often uses varied symbols, prefixes, suffixes, and functional acronyms.
  • This diversity in naming conventions leads to significant confusion and inconsistency in scientific literature and databases.

Purpose of the Study:

  • To address the redundancy and inconsistency in protein family nomenclature.
  • To propose a curated and standardized terminology for Mitogen Activated Protein Kinase (MAPK) families and similar protein groups.

Main Methods:

  • Review and analysis of existing nomenclature for protein families, focusing on MAPKs.
  • Development of a proposal for standardized naming conventions.

Main Results:

  • Identified significant issues with current MAPK nomenclature leading to data redundancy.
  • Presented arguable suggestions for a unified and consistent terminology.

Conclusions:

  • A systematic curation of protein family terminology is essential.
  • Standardized nomenclature for MAPKs will enhance clarity and reduce indexing errors.