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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Programmable Payload Release from Transient Polymer Microcapsules Triggered by a Specific Ion Coactivation Effect.

Shijia Tang1, Liuyan Tang1, Xiaocun Lu1

  • 1Beckman Institute for Advanced Science and Technology, ‡Department of Materials Science and Engineering, and ∥Department of Chemistry, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.

Journal of the American Chemical Society
|December 13, 2017
PubMed
Summary
This summary is machine-generated.

Researchers discovered a specific ion coactivation (SICA) effect in transient polymers. This finding enables the development of programmable microcapsules for controlled payload release using specific ion combinations.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Supramolecular Chemistry

Background:

  • Stimuli-responsive materials are crucial for chemical logic gates and signal amplification.
  • Characterizing coactivated responses in materials remains a challenge.

Purpose of the Study:

  • To demonstrate and characterize a specific ion coactivation (SICA) effect in transient polymer solids.
  • To develop programmable microcapsules based on the SICA effect.

Main Methods:

  • Investigated the depolymerization of cyclic poly(phthalaldehyde) (cPPA) core-shell microcapsules in acidic methanol solutions containing various ions.
  • Analyzed the influence of anions and cations on the depolymerization rate and correlated it with Hofmeister behavior.

Main Results:

  • A significant acceleration in cPPA depolymerization was observed upon coactivation by acid and specific ions.
  • The SICA effect was found to be primarily governed by anions, with cations playing a secondary modulating role.
  • Developed cPPA microcapsules with programmable payload release rates dependent on salt and acidic-methanol solution composition.

Conclusions:

  • The SICA effect provides a novel mechanism for controlling the degradation of transient polymers.
  • This study establishes a foundation for designing advanced responsive materials and smart delivery systems.