Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Water-stable α-cyclodextrin encapsulated CsPbBr<sub>3</sub> perovskite quantum dots for fluorescence detection of propiconazole.

Mikrochimica acta·2026
Same author

Covalent Network Formation Rate Controls Depletion-Induced Supramolecular Assembly in Hybrid Double Network Hydrogels.

Angewandte Chemie (International ed. in English)·2026
Same author

A Combined Approach: Karyotyping and QF-PCR for Comprehensive Genetic Screening in Male Infertility.

Biochemical genetics·2026
Same author

Plasmon Mode-Selective Gold Nanodimers with a Metal-Semiconductor Hybrid Junction.

ACS nano·2026
Same author

Design, Synthesis, and Characterization of <i>N</i>‑Doped Carbon Dots from a Ternary System of Citric Acid, Urea, and (<i>E</i>)‑2-(2,5-Dimethoxyphenyl)methylenebutane-1,4-dioic Acid.

ACS omega·2026
Same author

Taming the Achilles' Heel: A Chemical and Structural Design to Address Off-Target Effects in siRNA Therapeutics.

JACS Au·2026

Related Experiment Video

Updated: May 13, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

12.2K

DNA-Decorated Two-Dimensional Crystalline Nanosheets.

Shine K Albert1, Irla Sivakumar1, Murali Golla1

  • 1School of Chemistry, Indian Institute of Science Education and Research (IISER) Thiruvananthapuram , Trivandrum-695551, Kerala, India.

Journal of the American Chemical Society
|December 14, 2017
PubMed
Summary

Researchers developed a universal method to create DNA-decorated 2D nanosheets. This amphiphilicity-driven self-assembly strategy yields high aspect ratio sheets with precisely controlled DNA placement for advanced applications.

More Related Videos

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

7.2K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

12.2K

Related Experiment Videos

Last Updated: May 13, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

12.2K
Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

7.2K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

12.2K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biochemistry

Background:

  • Creating high aspect ratio 2D nanosheets with dense, information-rich surface molecules like DNA is a significant challenge.
  • Existing methods often struggle with precise control over surface decoration and molecular arrangement.

Purpose of the Study:

  • To develop a universal strategy for synthesizing high aspect ratio 2D nanosheets densely decorated with DNA.
  • To demonstrate DNA-directed surface addressability on these synthesized sheets.

Main Methods:

  • Utilizing amphiphilicity-driven self-assembly to form 2D sheets.
  • Employing microscopy and X-ray analyses to characterize the sheets' structure and crystallinity.
  • Demonstrating sequence-specific DNA hybridization for targeted gold nanoparticle decoration.

Main Results:

  • Successfully synthesized crystalline, high aspect ratio 2D nanosheets with densely packed DNA on their surface.
  • Confirmed DNA-directed surface addressability by selectively decorating sheet faces with gold nanoparticles via DNA hybridization.
  • Established a versatile platform for creating precisely functionalized DNA-nanosheet constructs.

Conclusions:

  • The amphiphilicity-driven self-assembly offers a universal strategy for DNA-decorated high aspect ratio nanosheets.
  • These DNA-functionalized sheets exhibit controlled surface addressability, enabling precise nanoscale engineering.
  • Potential applications span materials science, drug delivery, and nanoelectronics due to the tailored DNA presentation.