Related Experiment Video

Updated: Feb 17, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Integrin-β4 is a novel transcriptional target of TAp73

Ningxia Xie1,2, Polina Vikhreva1, Margherita Annicchiarico-Petruzzelli3

  • 1a MRC Toxicology Unit , Hodgkin Building , Lancaster Road, Leicester LE1 9HN , United Kingdom.

Cell Cycle (Georgetown, Tex.)
|December 14, 2017
PubMed

Insights

The p73 protein, a member of the p53 family, positively regulates integrin beta 4 (ITGB4), a gene involved in cell adhesion. This discovery sheds light on p73

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • The p73 protein is structurally and functionally similar to p53, a key tumor suppressor.
  • TAp73, a p73 variant, mimics p53's tumor suppressive functions like inducing apoptosis and cell cycle arrest.
  • p73 influences diverse cellular processes through context-dependent transcriptional regulation.

Purpose of the Study:

  • To investigate the regulatory role of p73 in cell adhesion.
  • To identify novel target genes of p73 involved in cell adhesion.

Main Methods:

  • Analysis of p73 and integrin beta 4 (ITGB4) gene expression.
  • Investigating the regulatory relationship between p73 and ITGB4.

Main Results:

  • p73 was identified as a positive regulator of the cell adhesion gene, integrin beta 4 (ITGB4).

Conclusions:

  • p73's role extends to regulating cell adhesion through ITGB4.
  • This finding contributes to understanding the broader biological functions of p73.
Keywords:
Integrinsadhesion and migrationcancer cellscell interactiononcogenes and tumor suppressorsoncosupressionp53 familyp73transcription factors

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