Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Ex vivo</i> localization of wireless implantable microdevice using high-resolution 3D imaging techniques.

Frontiers in bioengineering and biotechnology·2026
Same author

Molecular Evaluation of RNA-Based Immune Checkpoint Profiling in Clear Cell Renal Cell Carcinoma.

Journal of clinical medicine·2026
Same author

A novel TAp63γ-Airn regulatory axis governs early myogenic gene networks.

Biology direct·2026
Same author

Identification of Long Noncoding RNA by In Situ Hybridization Approaches.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

Targeting serine/glycine metabolism to attenuate IFN-γ- and IL-22-driven inflammation and hyperproliferation in psoriasis.

Cell death discovery·2026
Same author

WWOX maintains epidermal identity and suppresses EMT to prevent aggressive cutaneous squamous cell carcinoma.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Running exercise alleviates chronic heart failure by promoting cardiomyocyte autophagic flux through the NEAT1-QKI affecting Beclin1/LC3B mRNA stability.

Biology direct·2026
Same journal

The PTHR1/PKA/CREB1 axis promotes osteosarcoma progression by activating the PVT1/miR-590-3p/AXIN2 ceRNA network to induce epithelial-mesenchymal transition.

Biology direct·2026
Same journal

Identification and prognostic analysis of genes related to CTNNB1 mutations in hepatocellular carcinoma.

Biology direct·2026
Same journal

TrxR1 inhibition sensitizes hepatocellular carcinoma to Motesanib via an autophagy-ROS-JNK/ER stress axis.

Biology direct·2026
Same journal

Integrated microbiome-metabolome analysis implicates Acinetobacter guillouiae in arachidonic acid metabolic remodeling and endometrial cancer cell proliferation.

Biology direct·2026
Same journal

Comprehensive multi-omics analysis reveals a fatty acid metabolism gene signature for prognostic assessment and immunotherapy in nasopharyngeal carcinoma, and identifies ABCC1 as a potential novel therapeutic target.

Biology direct·2026
See all related articles

Related Experiment Video

Updated: May 31, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

Extracellular serine availability regulates inflammatory skin phenotypes.

Simone Sergio1,2, Alessandro Montella1, Mara Mancini1,2

  • 1Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.

Biology Direct
|May 29, 2026
PubMed
Summary
This summary is machine-generated.

A serine/glycine-free diet significantly reversed inflammation in a mouse model of psoriasis. This dietary intervention improved skin organization and reduced inflammatory cell infiltration, suggesting a link between amino acid metabolism and skin disease.

Keywords:
EpidermisInflammationPsoriasisSHMTsSerine metabolismSkin

More Related Videos

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation
07:11

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation

Published on: January 25, 2016

Related Experiment Videos

Last Updated: May 31, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation
07:11

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation

Published on: January 25, 2016

Area of Science:

  • Dermatology
  • Metabolic Research
  • Immunology

Background:

  • Serine regulates epidermal growth and skin repair.
  • Inhibiting Serine Hydroxy-Methyl Transferases (SHMTs) reduces skin inflammation.
  • The impact of serine/glycine-free diets on inflammatory skin conditions like psoriasis remains unexplored.

Purpose of the Study:

  • To investigate the role of serine/glycine availability in epidermal inflammation.
  • To determine the effect of a serine/glycine-free diet on psoriasis-like skin inflammation.

Main Methods:

  • A mouse model of inflammation was used.
  • Mice were fed either a standard diet or a serine/glycine-deprived diet.
  • Psoriasis-like skin inflammation was induced using IMIQUIMOD (IMQ).

Main Results:

  • A serine/glycine-free diet substantially reversed IMQ-induced skin inflammation.
  • Dietary changes altered keratinocyte proliferation, differentiation, and inflammatory cell infiltration.
  • Reduced epidermal thickening, improved skin organization, and decreased CD3+ T-lymphocyte infiltration were observed.

Conclusions:

  • Serine/glycine availability impacts epidermal inflammation.
  • A link exists between amino acid homeostasis and chronic inflammatory skin disease progression.
  • Metabolic strategies targeting serine metabolism may offer therapeutic potential for psoriasis and atopic dermatitis.