Related Experiment Video
Updated: Feb 17, 2026
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
A protocol for a systematic review of economic evaluation studies conducted on neonatal systemic infections in South
Shruti Murthy1, Denny John2,3, Isadora Perpetual Godinho4
1Department of Statistics, Prasanna School of Public Health, Manipal Academy of Higher Education, Level 6, Health Science Library Building, Madhav Nagar, Manipal, Karnataka, 576104, India. shruti.murthy@learner.manipal.edu.
Insights
This systematic review synthesizes economic evidence on managing neonatal systemic infections in South Asia. It highlights the need for more research on cost-effectiveness to improve infant health outcomes and reduce long-term burdens.
Area of Science:
- Public Health
- Health Economics
- Neonatal Medicine
Background:
- Neonatal systemic infections pose significant long-term health, economic, and social challenges.
- There is a notable lack of consolidated economic evidence regarding the management of these infections, particularly in South Asia.
- Existing economic evaluations often focus on the broader under-five age group, neglecting specific neonatal needs.
Purpose of the Study:
- To systematically review and critically appraise existing economic evaluations on the management of neonatal systemic infections in South Asia.
- To consolidate evidence on resource use, costs, and cost-effectiveness of interventions for neonatal infections.
- To identify research gaps and inform future economic evaluations in this critical area.
Main Methods:
- Systematic review including full and partial economic evaluations published in English.
- Comprehensive electronic searches across multiple databases (PubMed, EMBASE, EconLit, etc.) and grey literature.
- Independent screening, data extraction, and risk of bias assessment by two authors, with narrative synthesis and tabulation of results.
Main Results:
- The review aims to synthesize findings on the economic impact and cost-effectiveness of interventions for neonatal systemic infections.
- It will provide a comprehensive overview of current economic evidence specific to the South Asian context.
- The study will highlight methodological strengths and weaknesses of existing evaluations.
Conclusions:
- This review is the first to focus on economic evidence for neonatal systemic infections in South Asia.
- Findings will inform policymakers and healthcare providers on resource allocation and intervention strategies.
- The study will guide future research priorities to address critical gaps in economic evidence for neonatal health.
Background:
Neonatal systemic infections and their consequent impairments give rise to long-lasting health, economic and social effects on the neonate, the family and the nation. Considering the dearth of consolidated economic evidence in this important area, this systematic review aims to critically appraise and consolidate the evidence on economic evaluations of management of neonatal systemic infections in South Asia.
Methods:
Full and partial economic evaluations, published in English, associated with the management of neonatal systemic infections in South Asia will be included. Any intervention related to management of neonatal systemic infections will be eligible for inclusion. Comparison can include a placebo or alternative standard of care. Interventions without any comparators will also be eligible for inclusion. Outcomes of this review will include measures related to resource use, costs and cost-effectiveness. Electronic searches will be conducted on PubMed, CINAHL, MEDLINE (Ovid), EMBASE, Web of Science, EconLit, the Centre for Reviews and Dissemination Library (CRD) Database, Popline, IndMed, MedKnow, IMSEAR, the Cost Effectiveness Analysis (CEA) Registry and Pediatric Economic Database Evaluation (PEDE). Conference proceedings and grey literature will be searched in addition to performing back referencing of bibliographies of included studies. Two authors will independently screen studies (in title, abstract and full-text stages), extract data and assess risk of bias. A narrative summary and tables will be used to summarize the characteristics and results of included studies.
Discussion:
Neonatal systemic infections can have significant economic repercussions on the families, health care providers and, cumulatively, the nation. Pediatric economic evaluations have focused on the under-five age group, and published consolidated economic evidence for neonates is missing in the developing world context. To the best of our knowledge, this is the first review of economic evidence on neonatal systemic infections in the South Asian context. Further, this protocol provides an underst anding of the methods used to design and evaluate economic evidence for methodological quality, transparency and focus on health equity. This review will also highlight existing gaps in research and identify scope for further research.
Systematic Review Registration:
PROSPERO CRD42017047275.
More Related Videos
06:15Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
05:50International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure
Published on: March 12, 2020
Related Concept Videos
01:20Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
01:26Methods Of Healthcare Delivery System
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
01:29Bias in Epidemiological Studies