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Tim-4 expression increases in ischemic stroke patients and is associated with poor outcome
Liyun Xu1, Zhinan Ye2, Binda Wang2
1Celluar and Molecular Biology Laboratory, Zhoushan Hospital Affiliated to Wenzhou Medical University, Zhejiang 316021, China.
Journal of Neuroimmunology
|December 14, 2017
Summary
T cell immunoglobulin and mucin domain-containing protein 4 (Tim-4) on monocytes increases after ischemic stroke. Elevated Tim-4 levels predict stroke severity and patient outcomes, suggesting its potential as a prognostic biomarker.
Area of Science:
- Immunology
- Neurology
- Biomarker Discovery
Background:
- T cell immunoglobulin and mucin domain-containing protein 4 (Tim-4) plays a role in immune regulation.
- Monocytes are key immune cells involved in inflammatory responses, including those following ischemic stroke.
Purpose of the Study:
- To investigate Tim-4 expression on circulating monocytes and in plasma of patients with ischemic stroke.
- To determine the correlation between Tim-4 expression and stroke severity, infection, and patient outcomes.
Main Methods:
- Quantification of Tim-4 expression on monocytes and in plasma samples from ischemic stroke patients at different time points post-stroke.
- Correlation analysis between Tim-4 levels and clinical parameters such as stroke severity and occurrence of stroke-associated infection (SAI).
Main Results:
- Tim-4 expression on monocytes and in plasma was significantly increased on day 2 and day 5 after ischemic stroke.
- Increased Tim-4 expression positively correlated with stroke severity.
- Elevated Tim-4 levels on day 2 were associated with stroke-associated infection (SAI) and predicted poorer patient outcomes.
Conclusions:
- Tim-4 expression is upregulated in the acute phase of ischemic stroke.
- Tim-4 on monocytes and in plasma serves as a potential prognostic biomarker for ischemic stroke severity and outcomes.
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