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Tim-4 expression increases in ischemic stroke patients and is associated with poor outcome
Liyun Xu1, Zhinan Ye2, Binda Wang2
1Celluar and Molecular Biology Laboratory, Zhoushan Hospital Affiliated to Wenzhou Medical University, Zhejiang 316021, China.
Abstract:
T cell immunoglobin and mucin domain (Tim)-4 on monocytes is involved in immune regulation. Here, we investigated Tim-4 expression on circulating monocytes and in plasma of ischemic stroke. Tim-4 expression was significantly increased on day 2 and day 5 after stroke. Furthermore, stroke severity was positively correlated with Tim-4 expression on monocytes or in plasma. Increased Tim-4 expression was related to stroke associated with infection (SAI) on day 2. Up-regulated Tim-4 expression on monocytes or in plasma on day 2 was a risk predictor of outcome. Our findings suggest that Tim-4 can act as a prognostic biomarker of ischemic stroke.
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