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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

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JNK-signaling: A multiplexing hub in programmed cell death

Danny N Dhanasekaran1, E Premkumar Reddy2

  • 1Department of Cell Biology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma, OK, USA.

Genes & Cancer
|December 14, 2017
PubMed

Insights

Jun N-terminal kinases (JNKs) regulate cancer progression by controlling cell death pathways. Understanding JNK

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Cell Signaling

Background:

  • Jun N-terminal kinases (JNKs) are critical regulators in diverse signaling pathways implicated in cancer.
  • JNK signaling influences key cancer hallmarks including proliferation, migration, therapy resistance, and cell death.

Purpose of the Study:

  • To review the multifaceted roles of JNK signaling in programmed cell death.
  • To elucidate the impact of JNK-mediated cell death modulation on cancer growth, progression, and therapeutic responses.

Main Methods:

  • Literature review of studies investigating JNK signaling pathways.
  • Analysis of JNK's involvement in various programmed cell death mechanisms (apoptosis, necroptosis, ferroptosis, pyroptosis, autophagy).
  • Examination of JNK's regulatory mechanisms, including gene expression and protein phosphorylation.

Main Results:

  • JNKs regulate both apoptotic and non-apoptotic programmed cell death.
  • JNKs exert context-dependent control over cell death, either promoting or inhibiting it.
  • JNK activity impacts cancer progression through modulation of cell death pathways.

Conclusions:

  • JNK signaling is a key determinant of cancer cell fate.
  • Targeting JNK pathways offers potential therapeutic strategies for cancer treatment.
  • Further research into JNK's role in diverse cell death mechanisms is crucial for cancer therapy.
Keywords:
JNKapoptosiscell deathferroptosisnecroptosis

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