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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

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Amputation risk after the revascularization procedures in sarcoma resections.

Luiz Eduardo Moreira Teixeira^1,2, Thiago Marques Leão³, Daniel Barbosa Regazzi³

¹Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Belo Horizonte, MG, Brazil.

Revista Brasileira De Ortopedia

|December 14, 2017

Summary

This summary is machine-generated.

Vascular reconstruction after extremity tumor resection has a 38% amputation risk, particularly with bone sarcomas, prosthesis use, and infection. Soft tissue sarcomas had no amputations, highlighting infection as a key risk factor.

Keywords:

Amputation Limb salvage Osteosarcoma Reconstructive surgical procedures Soft tissue sarcoma

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Area of Science:

Orthopedic Surgery
Vascular Surgery
Oncology

Background:

Extremity tumors often require complex surgical management.
Vascular reconstruction is crucial for limb salvage after tumor resection.
Risk factors for amputation following such procedures require further elucidation.

Purpose of the Study:

To assess the effectiveness of vascular reconstructive surgery in limb salvage after bone and soft tissue tumor resection.
To identify predictors of amputation following these complex reconstructions.

Main Methods:

Retrospective observational study of 13 patients undergoing tumor resection and vascular reconstruction (2002-2015).
Data collected from medical records, analyzing correlations between patient/tumor factors and amputation.
Key factors analyzed included tumor type, reconstruction method, vascular patency, and infection.

Main Results:

Five of 13 patients (38.46%) required amputation post-reconstruction.
Amputation was significantly associated with bone sarcoma, orthopedic prosthesis use, failed vascular patency, and surgical site infection.
No soft tissue sarcoma patients underwent amputation; the sole bone sarcoma patient without amputation had no infection and maintained graft patency.

Conclusions:

Surgical site infection is a primary risk factor for revascularization failure.
Infection poses a significant threat to limb salvage, especially in bone sarcoma cases requiring non-conventional joint prostheses.
Maintaining vascular patency and preventing infection are critical for successful limb reconstruction outcomes.