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Related Experiment Video

Updated: Feb 17, 2026

Enrichment of Bruch's Membrane from Human Donor Eyes
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Corrugated Bruch's membrane in high myopia.

Jost B Jonas1, Rahul A Jonas2, Kyoko Ohno-Matsui3

  • 1Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

Acta Ophthalmologica
|December 14, 2017
PubMed
Summary

Bruch

Keywords:
Bruch′s membraneBruch′s membrane defectsemmetropizationhigh myopiamyopic maculopathymyopization

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Area of Science:

  • Ophthalmology
  • Histopathology
  • Biomedical Engineering

Background:

  • Axially elongated eyes, often associated with high myopia, present unique structural challenges.
  • Understanding the integrity of Bruch's membrane (BM) is crucial for comprehending ocular pathologies in these eyes.

Purpose of the Study:

  • To investigate the morphological characteristics of Bruch's membrane (BM) in axially elongated human eyes.
  • To determine the prevalence and associations of BM corrugation in this population.

Main Methods:

  • Histological examination of anterior-posterior sections from 85 human eyes.
  • Light microscopy was used to identify and define BM corrugation (>20 μm elevation over 50 μm basis).

Main Results:

  • Bruch's membrane (BM) corrugation was observed in 9.4% of the eyes studied.
  • BM corrugation showed a strong association with macular BM defects (OR: 418) but not with axial length.
  • Seven out of 13 eyes with macular BM defects exhibited BM corrugation.

Conclusions:

  • Bruch's membrane (BM) corrugation is linked to macular BM defects in highly myopic eyes, possibly due to regional tension differences.
  • BM corrugation may also occur near the optic disc in eyes with large parapapillary gamma zones.
  • These findings may contribute to understanding the etiology of axial myopia.